Opposite Charge Movements Within the Photoactive Site Modulate Two-Step Channel Closing in GtACR1
نویسندگان
چکیده
منابع مشابه
Intramembrane charge movements and excitation– contraction coupling expressed by two-domain fragments of the Ca21 channel
To investigate the molecular basis of the voltage sensor that triggers excitation–contraction (EC) coupling, the four-domain pore subunit of the dihydropyridine receptor (DHPR) was cut in the cytoplasmic linker between domains II and III. cDNAs for the I-II domain (a1S 1–670) and the III-IV domain (a1S 701-1873) were expressed in dysgenic a1S-null myotubes. Coexpression of the two fragments res...
متن کاملIntramembrane charge movements and excitation- contraction coupling expressed by two-domain fragments of the Ca2+ channel.
To investigate the molecular basis of the voltage sensor that triggers excitation-contraction (EC) coupling, the four-domain pore subunit of the dihydropyridine receptor (DHPR) was cut in the cytoplasmic linker between domains II and III. cDNAs for the I-II domain (alpha1S 1-670) and the III-IV domain (alpha1S 701-1873) were expressed in dysgenic alpha1S-null myotubes. Coexpression of the two f...
متن کاملGating mechanisms of a natural anion channelrhodopsin.
Anion channelrhodopsins (ACRs) are a class of light-gated channels recently identified in cryptophyte algae that provide unprecedented fast and powerful hyperpolarizing tools for optogenetics. Analysis of photocurrents generated by Guillardia theta ACR 1 (GtACR1) and its mutants in response to laser flashes showed that GtACR1 gating comprises two separate mechanisms with opposite dependencies o...
متن کاملheterogeneity within the orientalist discourse: representation of the orient in womens travelogues and mens paintings
from 1950s onward, new theories and critical approaches burgeoned across humanities. these theories were context-oriented; as a result, the analysis of discursive practices gained significance. thus, social, political, historical and cultural discourses that have been hitherto marginalized and considered inferior to literary texts, were introduced as important texts to be analyzed by critics. o...
Lagrangian Relaxation Method for the Step fixed-charge Transportation Problem
In this paper, a step fixed charge transportation problem is developed where the products are sent from the sources to the destinations in existence of both unit and step fixed-charges. The proposed model determines the amount of products in the existing routes with the aim of minimizing the total cost (sum of unit and step fixed-charges) to satisfy the demand of each customer. As the problem i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.10.009